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Correspondingly, intratumorally administration of RAMBO 1 week after tumor inoculation, and intraperitoneally administration of bevacizumab twice a week reduced migration as well as invasion of glioma cells [130]

Zhang W, He Q, Chan LL, Zhou F, El Naghy M, Thompson EB, Ansari NH: Involvement of caspases in 4-hydroxy-alkenal induced apoptosis in human leukemic cells

Previous studies identified LecRK-I.9 (DORN1) as a positive regulator of plant defense against the oomycete pathogens, Phytophthora brassicae , Phytophthora infestans , and bacterial pathogen Pseudomonas syringae DC3000 21,22,23,24,25

These effects collectively serve to protect cells from undergoing ferroptosis [79, 80]

The antigen variability could be responsible for the development of adaptive resistance, essentially the tumors ability to adapt dynamically to the immune attack