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[DOI] [PMC free article] [PubMed] [Google Scholar] 77.Weinreb R.N., Aung T., Medeiros F.A

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If the Cys to which HNE is bonded is located in a more hydrophobic region of the protein, the significant dipole moment of the aldehyde functionality of HNE will be a driving force to move that Cys closer to the surface of the protein, thereby exposing hydrophobic regions of the protein to the aqueous phase