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In particular, it was evaluated as having successfully captured the characteristics of Japanese smokers who prefer high-tar cigarettes and a clean taste, and the American-made Lucky Strike continued to be sold in Japan even after the filter version was discontinued in the U.S

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Overall, despite the few above-mentioned reports and the suggestion for a possible association between type V collagen defects and cardiovascular fragility demonstrated in Col5a1 and Col5a2 knock-out mice [124, 125], our results suggest that the risk for severe vascular complications seems to be fairly low in humans harboring a type V collagen defect and the presence of additional, yet unknown, genetic modifiers in families with a severe vascular phenotype is reasonable