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Canagliflozin (Cana), an anti-diabetes drug, also promotes the system Xc-/GPX4 axis to inhibit ferroptosis, attenuating cardiovascular diseases (Du et al

Furthermore, in rat models, the increased vascularity was associated with less survival

It plays roles in cell migration, inflammation regulation, wound healing, and angiogenesis

Sulforaphane selectively triggers apoptosis in GBM cells through activation of the ATF4CHOP axis [129], whereas the proteasome inhibitor marizomib upregulates ERS markers such as GRP78, IRE1, and CHOP to induce caspase-3-dependent apoptosis, independent of ROS and autophagy [130]

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