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Furthermore, OHP causes damage to both neuronal and nonneuronal mitochondria, leading to oxidative stress burden mediated by the redox-sensitive TRPA1 channels, which correlate with OHP-induced cold and mechanical hypersensitivity [71, 115,116,117]

The drop containing cells was covered with a glass cover slip and left at 4C for 5 min

The three amino acids affect the production of eumelanin (black/brown pigment) and pheomelanin (red/yellow pigment)

Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration

Overexpression of an AKT1 Cys77Ser mutant increased cell proliferation and DNA synthesis which could not be augmented by methylglyoxal treatment like the wild-type