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Voltage-dependent anion channel protein 1 (VDAC1) was identified as a highly abundant protein component in these EVs

Liver regeneration is significantly impaired in TGR5 KO mice compared to wild-type controls, highlighting the protective role of TGR5 in this process

For example, magnesium can increase neurotransmission by endogenous serotonin receptors (5-HT1A)

Then, there are special situations where first-line treatment may not be successful, as seen in difficult-to-treat AIH (DTT-AIH), AIH associated with cirrhosis and overlap syndrome