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Although this region of the enzyme has been confirmed to bind GSH and the C28-C31 pair has been observed to be necessary for the reduction of GSSG, there is no explicit evidence of how electrons are transmitted to the GR domain

10.3390/molecules22040555 Summary Keywords l-arginine, nitric oxide, cGMP, K ATP , cardiovascular disease, metabolic syndrome, pain, phytochemicals Citation Hosseini SZ, Abbaszadeh F, Alavi SD, Gravandi MM, Amirian R, Fakhri S and Echeverra J (2025) Targeting L-arginine/NO/cGMP/K ATP pathway by phytochemicals: therapeutic applications and clinical perspectives

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Serum zonulin and claudin-5 levels in children with attention-deficit/hyperactivity disorder

Existing reviews tend to fall into two categories: overly broad analyses that emphasize reactive oxygen species (ROS) biology without sufficiently addressing GSH, or highly focused discussions on chemical linkers that overlook translational relevance