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10.1053/j.gastro.2008.01.073 Gastroenterology 117 MariM.ColellA.MoralesA.von MontfortC.Garcia-RuizC.Fernandez-ChecaJ

41 Additionally, studies have reported that individuals with Type 2 diabetes mellitus (T2DM) have decreased GSH levels due to compromised GSH synthesis and metabolism enzymes

Nat Chem Biol 7 , 101105 (2011)

These effects are mediated by oxidative stress, nutrient competition, and enzymatic interference

The review confirmed that glutathione peroxidases detoxify peroxides by a reaction coupled to GSH oxidation to GSSG with GSSG converted back to GSH by glutathione reductase and NADPH