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, Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis, Mol

Ferroptosis regulates lipid peroxidation via the GPX4/acyl-CoA synthetase long chain family member 4 axis, and targeting of GSH metabolism selectively eliminates resistant subpopulations that are dependent on antioxidant defenses

NRF2 expression was markedly decreased in NSC-34 motor neuron cells transfected with the human SOD1 G93A gene, leading to significantly increased levels of MDA, GSH, and ROS, along with reduced expression of SLC7A11 and GPX4

First, both heme and Fe-S cluster biosynthesis occurs, in part, in mitochondria

Oxidative stress is linked to aging, chronic diseases, and toxicity, potentially increasing the risk of cancers and neurodegenerative disorders