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Moreover, granulosa cells dysfunction can directly reduce oocytes quality ( Programmed cell death (PCD), a genetically controlled process of cell death (Tower, 2015), plays an important role in regulating follicular development, maintaining hormone homeostasis, and modulating ovarian reserve (Wang et al., 2023a)

Cell culture Erythroid progenitors from SCD patients were generated with peripheral blood mononuclear cells (PBMN) followed by CD34+ cell selection (#17856, StemCell Technologies)