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Moreover, hormonal changes with aging such as insulin resistance, lower IGF-1 levels, and higher glucocorticoid levels can tilt the balance toward a catabolic state, meaning geriatric patients often have a blunted anabolic response even with adequate nutrients [69, 70]

Further research is needed to optimize the efficacy and safety of these therapeutic strategies and to translate preclinical findings into clinical applications for individuals with COPD (116)