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The intracellular and extracellular levels of S1P are spatially altered, allowing it to function as an autocrine or paracrine factor respectively, which is widely distributed in lymph and blood circulation and is believed to exist in the attenuation gradient from blood to tissues

In contrast to the anti-inflammatory effects of -3 fatty acids, -6 fatty acids exhibit pro-inflammatory effects, being converted into PGE1 or lipoxin A4, which promote inflammation (46)

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It does not directly influence pigmentation, oxidative damage, or detox pathways in the body

Stimulation of T cells with GABA also has been shown to inhibit the production of pro-inflammatory cytokines and therefore it attenuates the T cell response in inflammatory disease models such as EAE but also in Diabetes models (Soltani et al., 2011