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Methylfolate and other B vitamins act as cofactors in this process, including B12 and B6

Effect of coffee in lipopolysaccharide-induced indoleamine 2,3- dioxygenase activation and depressive-like behavior in mice

226-228 A trial in which 36 subjects with fibromyalgia received placebo and increasing doses of melatonin (3 mg, 6 mg, 9 mg, 12 mg, and 15 mg nightly) during alternating 10-day cycles found 9 mg, 12 mg, and 15 mg of melatonin per day decreased scores on the Fibromyalgia Impact Questionnaire, number of tender points, and urinary cortisol levels

These findings offer important insights into the neurobiological mechanisms underlying depression [374]

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