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Description

In brief, NRF2 detaches from Kelch-like ECH-associated protein 1 and translocates to the nucleus, where it activates the expression of downstream target genes containing antioxidant responsive elements

The role of biotransformation and bioactivation in toxicity

It's a degenerative joint disease (often called the "wear-and-tear" type) in which the smooth lining of cartilage becomes thinned and uneven, exposing the bone beneath