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This was evidenced by in vivo studies, which revealed a markedly reduced expression of PGC-1 and its target genes in the striatum and muscle of HD mice ( A number of in vivo studies have demonstrated that mHtt is involved in the process of mitophagy or regulates intermediately important aspects in animal models of HD

Further, as discussed in more detail in another section of this final rule with comment period, although the new requirements at 180.50 will be effective January 1, 2026, we are delaying enforcement of these requirements to April 1, 2026, to provide hospitals with more time to comply

These signs can point to serious conditions like thyroid disease or peripheral vascular disease

However, the scientific rationale suggests that their different mechanisms could complement each other

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