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New 4 th generation e-cigarettes like Juul and other pod mods contain high concentrations of nicotine about 5% or 59mg/ml Most of them also use nicotine salts, which can deliver a higher concentration without as much throat irritation as would be the case with the freebase nicotine used in earlier e-cigarettes

The United States Centers for Disease Control and Prevention have suggested that smokers who are unable to quit smoking may benefit by switching from smoking cigarettes to vaping e-cigarettes if they switch completely and are able to avoid relapsing to cigarette smoking

In addition, nicotine seems to undo the benefits of chemotherapy

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