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Cigarette smokers, both adults and adolescents, are more likely than nonsmokers to use illicit drugs, including cannabis, alcohol, and cocaine, and to meet criteria for substance use disorders.718 Illicit drug use is also associated with decreased likelihood of smoking cessation,19,20 and illicit drug use disorders are associated with the persistence of nicotine dependence over time.19 Cannabis use is further associated with increased risk of relapse to cigarette use among former smokers.21 The use of illicit drugs, most notably cannabis, has increased in the general population over the last several years.2227 Recent studies also suggest increases in mental health problems in the United States, including depression, which is strongly associated with smoking.28 In addition, a growing number of studies have shown that the prevalence of smoking has declined less rapidly among those with mental health problems,29,30 relationships between cigarette smoking and substance misuse or mental health problems have become stronger over time,31,32 mental health problems have increased among cigarette smokers,3335 and quit rates are lower among persons with alcohol use problems36 or mental disorders.37,38 However, prior studies have not yet examined trends in the prevalence of illicit drug use, nor in the use of specific types of illicit drugs, by cigarette use status over time in recent years

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