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Genes and environment TUD has been genetically correlated with smoking and psychiatric traits ( Nicotine is the main psychoactive component of tobacco ( Based on a recent genome-wide multivariate association meta-analysis that breaks down the contribution of general and substance-specific loci, a polygenic addiction risk score was associated with SUD, other mental symptoms or psychiatric disorders, somatic conditions, and settings associated with addiction onset

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Cotinine has a half-life of about 16 hours, but it may take up to 40 hours to be eliminated from the body