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[9] Leukoplakia is, therefore, the most common premalignant lesion that occurs in the mouth

Other studies have proposed this to be a potentially promutagenic effect, which is to say that sperm with altered DNA may lead to health problems in the offspring.

More immigrants arrived after the English responded forcefully to the 1644 uprising and destroyed most Native American towns near the settled area, increasing the sense of personal security in the colony at the same time the Civil War in England reduced personal security at home

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