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to adults 21 and older, it doesn't mean these products, which contain nicotine, are considered safe or "FDA approved." The agency said, "There is no safe tobacco product" and people under 21 should not use it

Methods Overview For the present study, we used a meta-analytic tool, MR-BRT (metaregressionBayesian, regularized, trimmed), to estimate the doseresponse risk curves of the risk of a health outcome across the range of current smoking levels along with uncertainty estimates 28

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Using the pooled data for this time period, we calculated a gold standard estimate of cigarette smoking prevalence for each county in the validation set