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In addition, better powered studies would probably have detected a much broader range of adverse biological effects associated with the additives than identified to those identified in PM's published papers suggesting that the published papers substantially underestimate the toxic potential combination of cigarette smoke and additives

This triggers the adrenal glands to release adrenaline, causing blood glucose levels to rise

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For tobacco flavor specifically, nic salts let the actual tobacco taste come through rather than getting masked by harshness