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Krusty was introduced in Episode 7 of Season 3 of the original show, a mere three episodes after the first appearance of Itchy & Scratchy and 2 episodes after Homer uttered his first immortal D'oh!

Since DNA oxidation is implicated with mutation and cancer, p-BSQ may be a major factor for the cause of cancer by cigarette smoke

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Tobacco smoking is heavily associated with respiratory diseases such as chronic obstructive pulmonary disease (COPD), emphysema, chronic bronchitis, asthma, and lung cancer

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