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The 2015 SimSmoke male (female) projected prevalence were outside the TUS 95% CI, but the relative reductions between 1993 and 2015 were 44.7% for males and 43.8% for females and were within 3% of the TUS estimates for both males (41.9%) and females (42.7%)

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As with e-cigarettes, the WHO does not support HTPs for harm reduction, stating that while the toxicants in HTP smoke are generally lower than those found in conventional cigarettes, the levels of some toxicants are higher and there are new substances absent in tobacco smoke which could potentially harm human health. They also claim there is no evidence to demonstrate that HTPs are less harmful than conventional tobacco products (WHO, 2020)

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