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In analyses adjusted for age and WTAR score, participants with combined recreational-therapeutic use performed 0.28 standard deviations better than participants with predominantly-recreational use ( = 0.28, 95% 0.02, 0.57, p = 0.067)

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To best create these translatable pre-clinical animal models, it is necessary to standardize factors such as puff frequencies and topographies, exposure concentrations, e-liquid composition and device generation/brand to ensure consistent E-cigarette Vapour Deposition

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