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That cell (which can be bacteria, yeast or animal cells) will now produce the insulin along with all its own proteins

The original "Sad Affleck" meme (not to be confused with the smoking format) refers to the look of dismay worn by Affleck during a Batman v Superman press interview in 2016, which went viral paired with Simon & Garfunkel's "The Sound of Silence." The two memes have always been linked in the public consciousness different moments, same essential emotional frequency