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This significant gap in knowledge calls for further investigation: as experts have noted, understanding the full extent of e-cigarette effects on the developing lungs is critical for guiding public health policy and clinical recommendations (16)

Current depressive symptoms and lifetime diagnosis To account for the presence of both lifetime and current depression simultaneously, a variable was constructed with the physicians diagnosis and the PHQ-9 cutoff with four levels: no current symptoms & no lifetime diagnosis (PHQ-9 sum score 10 10

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