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In the Surgeon Generals 2012 report on Preventing Tobacco Use Among Youth and Young Adults, the epidemiological research showed that adolescence and young adulthood represent[s] a time of heightened vulnerability to tobacco use and the initiation of cigarette smoking. The rationale behind increasing the age from 18 to 21 is to reduce the number of people who begin smoking (or vaping) by making it more difficult to access tobacco during the years of highest vulnerability

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Dose reduction is not required in patients with mild-to-moderate renal impairment

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For food and beverages, these agreements can be either formal or informal