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The tobacco industry long ago determined the optimum level of nicotine to hook people and sustain their addiction, the FDA noted in its proposal

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However, for people who are not currently smoking, oral nicotine product use can lead to nicotine dependence, and a growing number of studies around use of nicotine products have found that nicotine dependence may be predictor of lifelong tobacco use and addiction as well as dual use of combustible tobacco and other forms of nicotine