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Another mechanism by which CBD induces apoptosis is increasing the expression of death receptor-5 (DR5), to which TNF-Related Apoptosis-Inducing Ligand (TRAIL) binds and stimulates apoptosis in colorectal cancer cells, which in return increases the sensitivity to TRAIL leading to increased apoptosis in CRC, but it didnt affect the normal colorectal cells

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Nitric oxide (NO) is a molecule and gas that is released naturally in the body including from the lining of blood vessels

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