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Additionally, the reduced blood circulation caused by nicotine can further impair the bodys natural ability to repair damaged tissue, exacerbating the problem

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These data illustrate a specific challenge in studying the potential effects and harms of nicotine as much of the research into the potential harms of nicotine comes from studies in cells and animals where the doses used are often very high, leading to results that are controversial and difficult to extrapolate to humans

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