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Notably, translation- and protein control-related molecules seem to differ in RBCs from different pathophysiological backgrounds, such as with glucose-6-phosphate dehydrogenase deficiency (Tzounakas et al., 2022b), beta-thalassemia trait (Anastasiadi et al., 2021b), and hereditary xerocytosis (Caulier et al., 2022), adding complexity to these simple cells

Mitochondria, in addition to regulating cellular energy conservation, serve as signaling organelles

Local Institutional Ethics Committee at each center approved the study and all patients or their parents signed the informed consent

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