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doi: 10.1074/jbc.M113.455899

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Proteolysis targeting chimeras (PROTACs) are bifunctional small molecules consisting of two specific ligands: one for an E3 ubiquitin ligase and another that binds to a target protein

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To visualize cell death in the spheroids

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This means there is as build-up of toxic porphyrins particularly uroporphyrin and coproprophyrin, which leads to blistering

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The peptide signals fibroblasts during the natural healing window when theyre most receptive

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