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Because there are similar amounts of other constituents in tobacco (e.g., TSNAs, metals, nitrates, and nitrites), regardless of the FTC ranking of the cigarette brand, more intense smoking to obtain a desired dose of nicotine leads to higher exposure to carcinogens
Evidence of the potential cardiovascular harm of NTPs, especially e-cigarettes, comes from preclinical studies using animal models that mimic human usage during pregnancy, which have shed light on their detrimental health impact on fetuses and children/offspring who are involuntarily exposed
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