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"I quit on November 1, 2010," she says, "and a year later, they told me I needed a lung transplant." The transplant, which she got 18 months ago, was necessary because she had end-stage emphysema

Specifically, SIRT1 expression decreased at 4, 12, 24, 36, and 48 hours post-CSE exposure relative to baseline ( Figure 4 )

Our studys major finding is that switching from combustible cigarettes to IQOS only moderately reduced the induction of lung endothelial damage compared to continued chronic cigarette smoke exposure

macrophage activity is diminished and an inflammatory response promoted