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Is Nicotine Really That Unhealthy? Why Nicotine is a Gateway Drug National Institutes of Health (NIH) Smoking and vaping are often compared, but neither is harmless. While they work differently, both can expose the lungs to addictive nicotine and harmful chemicals that impact breathing and overall health. Smoking Nicotine vs. Tobacco: Is Nicotine Dangerous on Its Own? Peter Attia Synthetic Nicotine vs. Tobacco Nicotine CHEMNOVATIC
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