legal age to smoke cigarettes in us History of tobacco minimum purchase by U.S. jurisdiction Massachusetts Becomes Sixth State to

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The authors suggest that impairments in neurological circuits controlling behavior may underlie impulsive, violent behavior, as a result of cannabis altering the normal neural functioning in the ventrolateral prefrontal cortex

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Cannabis dependence is a pattern of cannabis use that leads to clinically significant impairment or distress and is characterized by a cluster of behavioral, cognitive, and physiological symptoms indicating that the individual continues use despite substance-related problems