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However, contrary to modern health concerns, ancient southeast Asia literature suggested some positive medicinal effects, such as good oral health, digestive properties, protection from infections and headaches

However, the effects of alcohol consumption on four cancer mortality subtypes were greater in models that did not control for health expenditure, meaning that health expenditure may confound the association of interest and that its inclusion in the model helps isolate the specific contribution of alcohol consumption to cancer mortality trends

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Many of these products likely served as an effective harm-reduction for a subset of nicotine consumers who otherwise would have continued smoking