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Figure 1a, b, f, i, j source data is described in Supplementary Data 1, Fig

Today, weve announced two significant milestones to enhance our next-generation product business globally, further enabling us to meet the demands of todays consumer. Commenting on the deal, Bonnie Herzog, managing director of beverage, tobacco and convenience-store research at Wells Fargo Securities LLC, New York, said, We believe this strategic framework could ultimately have a significant positive financial impact, particularly for RAI, since RAI's licensing arrangement with BAT allows RAI to participate in the global e-cig category, which we continue to anticipate will generate significant growth and profits. She continued, By joining forces and leveraging each other's strengths, these two companies will likely accelerate the pace of e-cig/vapor/reduced risk products' growth on a global basis and importantly will be able to more successfully engage with regulators both in the U.S

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Prime Minister Rishi Sunak said: "If we want to build a better future for our children we need to tackle the single biggest entirely preventable cause of ill-health, disability and death: smoking

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