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(The District of Columbia has the highest tax at $4.50 and Missouri has the lowest at 17 cents.) 6-8 All other tobacco products are taxed at 68% of the manufacturers list price.6 Clean indoor air ordinances Smoking is prohibited in all government and private workplaces (nonpublic workplaces with three or fewer employees are exempt), schools, childcare facilities, retail stores and recreational/cultural facilities.7 Smoking restrictions are required in restaurants, bars and casinos/gaming establishments.7 Exemptions exist for establishments that do not allow anyone under 21 to enter

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Furthermore, no other model to date has demonstrated such a high level of bio-model complexity, as our study highlights the importance of co-culture systems and the inclusion of macrophages in smoke exposure models, which are essential for capturing the immune-inflammatory responses involved in COPD pathogenesis

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