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5 A), indicating that these cells are undergoing a complex reactive transformation, characterized by ECM remodeling (MMP2, PCOLCE, LAMC2, ADAMTS19, ASPN, OGN, MFAP4, ANGPT2 and collagens COL6A3, COL12A1, COL28A1, COL2A1), cell adhesion, migration and astrocyte-ECM interactions (LOXL2, LAMC2), altered synaptic support and plasticity (WNT7A, LRRTM1, RELN, AGRN), neuroinflammatory signaling (TRIL), reduced regenerative capacity (GDF10, FGFR2) and decreased support to neuron integrity and survival (NDNF, COL2A1 and GDF10)

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doi: 10.1002/9781119436812.ch55 Summary Keywords triple-negative breast cancer (TNBC), dihydroartemisinin (DHA), transferrin (TF), TRAIL-induced apoptosis, death receptor (DR) Citation Zhou X, Soto-Gamez A, Nijdam F, Setroikromo R and Quax WJ (2022) Dihydroartemisinin-Transferrin Adducts Enhance TRAIL-Induced Apoptosis in Triple-Negative Breast Cancer in a P53-Independent and ROS-Dependent Manner

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C16-carnitine can induce IL-6 secretion and gene expression in PC3 cells [58]

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N., Assimos, D

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Studies confirmed that animals lacking these receptors showed no lipolytic response, validating this as the primary pathway

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