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TCAs also have significant cardiovascular risks (elevated blood pressure, rapid heartbeat, palpitation, arrhythmias), and the new SSRIs, while having numerically fewer side effects, have as their primary disadvantage frequent reports of anxiety, insomnia, nervousness, and tremor.32, 33 Believe it or not, with these common adverse side effects, none of these drugs list coffee as a beverage to avoid in their professional or patient literature

Clevelands daughter had died in 1904 17 years before the candys creation so Curtiss explanation didnt make much sense