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Amongst 2,488 people with severe very severe COPD who were susceptible to exacerbations, WISDOM (2014) compared triple therapy for up to 1 year (tiotropium 18 mcg/d + salmeterol 50 mcg twice/d + fluticasone 500 mcg twice/d) with gradual withdrawal of fluticasone over a 12-week period (followed by LAMA/LABA alone)

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