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Clinically, bipolar disorder often initially presents with a major depressive episode, with its defining feature, mania, only emerging after months or years, resulting in considerable delays 5

However, the FDA also made clear that IQOS cannot be endorsed or promoted as safe or "FDA approved." All tobacco products are potentially harmful and addictive, the FDAs statement read at the time

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In every year between 2002 and 2014, the percentage of recent initiation of smokeless tobacco use among those who were at risk for initiation was higher among males than females