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4,13 Factors affecting cellular immunity such as HIV infection, solid organ or haematological transplantation, use of tumour necrosis factor inhibitors, prolonged corticosteroid use, diabetes mellitus and end-stage renal disease are all known to increase the risk of progression to active tuberculosis disease (Box 1)

Persistent exposure to smoke-related inflammatory stimuli can drive repeated immune activation and antigenic load, conditions known to hasten the transition from functional memory responses toward senescent immune phenotypes (75)

Unlike Virginia tobacco, this type is air-cured

"Brian Wilson's Wave"

Begin by addressing the ceilings and windows, as these can be common places for smoke and soot to accumulate