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These receptors regulate important functions in the human body such as appetite, sleep and pain control, among others

Given that tobacco is being substituted in great part by e-cigarettes with different chemical compositions, manufacturers claim that e -cigarette will not cause lung diseases such as lung cancer, chronic obstructive pulmonary disease, or cardiovascular disorders often associated with conventional cigarette consumption [3, 94]

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5 Much to learn about toxicity Partly because vaping devices have been available to US consumers only since 2007, limited evidence is available regarding the long-term effects of exposure to the aerosol from these devices in humans

Given the wide variety of e-cigarette products on the market, more evidence is needed to evaluate the relative harm between e-cigarettes and combustible cigarettes, particularly for long-term users 32