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We found that: (a) GSH was higher in older adults only in the IFC, (b) there was a relationship between GSH baseline levels and short-term memory and working memory in young and older individuals respectively, yet with opposite directions, (c) at the group level there were no significant GSH changes as a result of cognitive task performance in neither region nor group, (d) there was an effect of sustained cognitive effort on GSH levels, which was dependent on the brain region and (e) the task-induced GSH modulation in both regions predicted cognitive performance only in young adults