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major components of reward circuitry in addiction of which nicotine enhances through this pathway ( It has been posed that nicotine leads to increases in dopamine levels within prefrontal regions through direct and indirect (GABA and glutamate influences) enhancement of dopaminergic activity that makes up for the lowered dopamine D1 stimulation and ensuing cognitive deficits observed in SZ (103)

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They used a high quality (strict) test of outcome by looking at studies which measured abstinence from smoking after at least six months follow up