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The effect sizes of smoking-related SNPs were acquired from a meta-analyzed GWAS summary association data from 1,232,091 individuals with predominantly European ancestry [30, 33], including age of smoking initiation (a continuous phenotype), smoking initiation (a binary phenotype, ever being a regular smoker), cigarettes per day (a continuous indicator of smoking heaviness), and smoking cessation (a binary phenotype, contrasting current versus former smokers)