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For example, in its press release announcing its product launch, NIIN wrote: Since our synthetic nicotine pouches are not derived from tobacco, they are not classified as a tobacco product, which means that they are not currently under FDA regulation. In its e-mail announcing its synthetic nicotine disposable e-cigarette, Pacha Mama went so far as to say No PMTA required, referring to the Premarket Tobacco Product Application the FDA requires manufacturers submit for new tobacco products

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The short duration of each puff (3 seconds) could appear therefore to be the main limiting factor because the best combination of temperature and heating time is required for optimal decarboxylation

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