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For example, on tasks of emotional memory, OC users exhibit attenuated bilateral amygdala response when exposed to negatively valenced, emotionally arousing stimuli compared to nonusers, 90 whereas in tasks examining aspects of fear (ie, conditioning, extinction, and recall), women taking OCs show lower activations in the insular and cingulate cortices, amygdala, hippocampus, and hypothalamus than naturally cycling (NC) women with high estrogen levels

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As of June 30, 2025, approximately 34 million adult smokers were using our leading heated tobacco product.1 The shipment volume of our heated tobacco unitsthe consumable element of our leading smoke-free producthas risen from 7 billion in 2016 to 140 billion in 2024